Combination of plasma amyloid beta(1-42/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology
نویسندگان
چکیده
منابع مشابه
Myxopapillary ependymoma with pleuropulmonary metastases and high plasma glial fibrillary acidic protein levels.
Introduction Myxopapillary ependymoma is a rare glial tumor with almost exclusive localization in the distal spinal cord (intraspinal variant) or the sacrococcygeal subcutaneous tissue (extraspinal variant). The average age at manifestation has been reported to be approximately 36 years. The overall incidence is approximately 0.08 per 100,000 persons per year for males and 0.05 per 100,000 pers...
متن کاملPlasma glial fibrillary acidic protein levels in a child with sickle cell disease and stroke.
A 12-year-old boy with HbSS sickle cell disease (SCD) was admitted with an acute febrile illness and developed overt stroke 3 days later. Plasma glial fibrillary acidic protein levels were elevated, as compared to pediatric controls, 32 h prior to the clinical diagnosis of stroke, peaked immediately prior to the exchange transfusion, and remained elevated 1 year later despite chronic transfusio...
متن کاملModelling and Characterization of Glial Fibrillary Acidic Protein
Glial Fibrillary Acidic Protein (GFAP) is an intermediate-filament (IF) protein that maintains the astrocytes of the Central Nervous System in Human. This is differentially expressed during serological studies in inflamed condition such as Rheumatoid Arthritis (RA). Therefore, it is of interest to glean molecular insight using a model of GFAP (49.88 kDa) due to its crystallographic nonavailabil...
متن کاملSpecificity of the glial fibrillary acidic protein for astroglia.
Glial fibrillary acidic protein (GFA) is the main constituent of glial filaments and the close similarity of GFA and neurofilament protein has been recently reported. However, the immunofluorescence staining of peripheral nerve which may be observed with GFA antisera is not due to cross-reaction between GFA and neurofilament protein. Staining of peripheral axons was also observed with control s...
متن کاملSpreading depression increases immunohistochemical staining of glial fibrillary acidic protein.
Reactive astrocytosis is a process by which astrocytes respond to brain injury by showing an increase in glial fibrillary acidic protein (GFAP) staining that is associated with hypertrophy and/or hyperplasia of these cells. Because spreading depression (SD) is a perturbation uncomplicated by neuronal necrosis and is seen in both in vivo and in vitro neural structures, we sought to determine whe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Alzheimer's Research & Therapy
سال: 2020
ISSN: 1758-9193
DOI: 10.1186/s13195-020-00682-7